ROS-RESPONSIVE NANOPARTICLE-MEDIATED DELIVERY OF CYP2J2 GENE FOR THERAPEUTIC ANGIOGENESIS IN SEVERE HINDLIMB ISCHEMIA

ROS-responsive nanoparticle-mediated delivery of CYP2J2 gene for therapeutic angiogenesis in severe hindlimb ischemia

With critical limb ischemia (CLI) being a multi-factorial disease, it is becoming evident that gene therapy with a multiple bio-functional growth factor could achieve better therapeutic outcomes.Cytochrome P450 Splatter Screens epoxygenase-2J2 (CYP2J2) and its catalytic products epoxyeicosatrienoic acids (EETs) exhibit pleiotropic biological activi

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